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Scritto da BMC Pharmacology
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 Background:Linaclotide has been proposed as a treatment for the same gastrointestinal indications for which lubiprostone has been approved, chronic idiopathic constipation and irritable bowel syndrome with constipation. Stressors damage the epitheli ... ...
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Scritto da Journal of Inflammation
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 Background:Activation of the endothelium, complement activation and generation of cytokines are known events during ischemia-reperfusion (I/R) that mediate tissue injury. Our aim was to elucidate their respective participation at the onset of the re ... ...
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Scritto da Journal of Inflammation
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 Background:The goal of the present study was to explore the effect of medications that are commonly prescribed for CKD patients on uremic state.Methods:This was a cross-sectional study. From January 2006 to October 2009, 1,623 patients with end-st ... ...
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Serotonin (5-hydroxytryptamine; 5-HT) delivered over 1 week results in a sustained fall in blood pressure in the sham and deoxycorticosterone acetate (DOCA)-salt rat. We hypothesized 5-HT lowers blood pressure through direct receptor-mediated vascula ... ...
The aim of this study was to investigate the hepatoprotective effect of Matrine salvianolic acid B salt on carbon tetrachloride (CCl4)-induced hepatic fibrosis in rats. Salvianolic acid B and Matrine has long been used to treat liver fibrosis. Matrin ... ...
Background:Inflammation in adipose tissue (AT) during obesity causes impaired AT function. Althoughmultiple extracellular matrix (ECM) proteins are expressed in AT their potential role inadipose tissue inflammation is unclear. Biglycan, a pro-inflam ... ...
Title: U.S. Bests Canada, Europe in Drug Approvals