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The change in Ig regulation from children to adults disconnects the correlation with the 3¿RR hs1.2 polymorphism
Scritto da BMC Immunology   
AllergologiaBackground:In the immune system, the serum levels of immunoglobulin (Ig) increase gradually during ageing. Through B cell development, the Ig heavy chain expression is modulated by a regulatory region at the 3? of the constant alpha gene (3?RR), in ... ...
 
Carbon monoxide down-regulates ¿4ß1 integrin-specific ligand binding and cell adhesion: a possible mechanism for cell mobilization
Scritto da BMC Immunology   
AllergologiaBackground:Carbon monoxide (CO), a byproduct of heme degradation, is attracting growing attention from the scientific community. At physiological concentrations, CO plays a role as a signal messenger that regulates a number of physiological processe ... ...
 
Multiple factors influence the contribution of individual immunoglobulin light chain genes to the naïve antibody repertoire
Scritto da BMC Immunology   
AllergologiaBackground:The naïve antibody repertoire is initially dependent upon the number of germline V(D)J genes and the ability of recombined heavy and light chains to pair. Individual VH and VL genes are not equally represented in naïve mature B cells, sug ... ...
 
Drug developed at Pitt proves effective against antibiotic-resistant 'superbugs'
Scritto da Immune System/Vaccines News From Medical News Today   
AllergologiaA treatment pioneered at the University of Pittsburgh Center for Vaccine Research (CVR) is far more effective than traditional antibiotics at inhibiting the growth of drug-resistant bacteria... ... ...
 
Specific gene variant may influence effectiveness of flu vaccine, study finds
Scritto da Immune System/Vaccines News From Medical News Today   
AllergologiaIn a new study, researchers from Switzerland find that a variant in the IL-28B gene may influence how the immune system responds to the annual flu vaccine. ... ...
 
Immunotherapy shows clinical benefit in nearly half of blood cancer patients who had relapsed following allogeneic stem cell transplantation
Scritto da Immune System/Vaccines News From Medical News Today   
AllergologiaA multicenter phase 1 trial of the immune checkpoint blocker ipilimumab found clinical benefit in nearly half of blood cancer patients who had relapsed following allogeneic stem cell transplantation... ... ...
 
Immunity to many types of flu viruses boosted by seasonal flu vaccines
Scritto da Immune System/Vaccines News From Medical News Today   
AllergologiaSeasonal flu vaccines may protect individuals not only against the strains of flu they contain but also against many additional types, according to a study published this week in mBio®, the... ... ...
 
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