|Gene of the month: PTEN|
|Scritto da Journal of Clinical Pathology|
Phosphatase and tensin homologue deleted on chromosome 10 (PTEN), also referred to as mutated in multiple advanced cancers (MMAC1) and TGF-β regulated and epithelial cell enriched phosphatase (TEP1), was first discovered in 1997.
This article highlights the important aspects of structure, function, mutations and role in cancer that are of relevance to the practicing pathologist. For more detailed information on these aspects the reader should refer to recently published articles.
The PTEN gene, mapped to 10q23.3, contains nine exons and encodes a 47 kD protein with 403 amino acids. Exons 1–6 code for the N-terminal domain,...