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Scritto da Nature Reviews: Genetics
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 Petruk et al. studied how the histone marks H3K4me3 and H3K27me3 are inherited to daughter chromosomes during DNA replication in Drosophila melanogaster embryos. Using various methods to track protein dynamics following replication fork passage, they ... ...
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Scritto da Nature Reviews: Genetics
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 In this study, the evolutionary forces acting on four wild populations of the house mouse Mus musculus were analysed by high-density SNP-genotyping arrays. Statistical analysis showed evidence for selective sweeps at rare and newly mutated alleles, i ... ...
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Scritto da Nature Reviews: Genetics
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 Raiber et al. mapped the genome-wide distribution of the DNA demethylation intermediate 5-formylcytosine (5fC) in mouse embryonic stem cells by developing a method to covalently tag and purify 5fC-containing DNA fragments that is then followed by hig ... ...
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The authors outline the focus of the encyclopaedia of mouse DNA elements (Mouse ENCODE), which is already underway. The project will functionally annotate the mouse genome using the same experimental pipelines that were established for human ENCODE. ... ...
Groundbreaking technical advances have opened the door for whole-genome analysis in prenatal genetic diagnosis (PND), and recently the proof-of-principle has been provided that non-invasive reconstruction of the entire fetal genome from a maternal bl ... ...
Pre-implantation genetic screening (PGS) is an adjunct technology to in vitro fertilization (IVF) that involves carrying out biopsies and testing embryos of subfertile couples to improve the chances of a successful pregnancy. Until now, PGS has been ... ...
As the list of genetic variants that are implicated in disease gets longer, the challenge is to understand how they contribute to disease phenotypes. A recent study describes a high-throughput yeast system for detecting the effects of disease alleles ... ...