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Prediction of breast cancer risk by genetic risk factors, overall and by hormone receptor status
Scritto da Journal of Medical Genetics current issue   
BiochimicaObjective

There is increasing interest in adding common genetic variants identified through genome wide association studies (GWAS) to breast cancer risk prediction models. First results from such models showed modest benefits in ter ... ...

 
Epigenomics: Dissecting the roles of Pol V
Scritto da Nature Reviews: Genetics   
BiochimicaRNA POLYMERASE IV (Pol IV) and Pol V are multi-subunit polymerases that are unique to plants and that evolved from Pol II; they mediate RNA-directed DNA methylation at CG, CHG or CHH (where H is any base other than G) sequences through the production ... ...
 
Gene therapy: Single-stranded RNAs for potent RNAi
Scritto da Nature Reviews: Genetics   
BiochimicaIn the development of gene-based therapies, delivery of ssRNAs is simpler than it is for dsRNAs (as this requires lipid formulation, for example). However, ssRNAs have previously been found to be far less potent for gene silencing. Lima et al. have n ... ...
 
Cinical genomics: Sequencing to track bacterial infection outbreaks
Scritto da Nature Reviews: Genetics   
BiochimicaThe use of genome sequencing to research disease outbreaks retrospectively has been demonstrated by high-profile cases, such as the recent cholera outbreak in Haiti. But can whole-genome sequencing be used to provide information that can be used in c ... ...
 
Human genitics: Determining de novo mutation rates
Scritto da Nature Reviews: Genetics   
BiochimicaKnowing the human de novo mutation rate is important for understanding our evolution and the origins of genetic diseases. These two papers characterize the de novo mutation rate, both using Icelandic families. Kong et al. sequenced the whole genomes ... ...
 
Chromatin: A model for nucleosome positioning
Scritto da Nature Reviews: Genetics   
BiochimicaNucleosome positioning is influenced by DNA sequence preferences and by various protein complexes, but the relative contribution of these influences has been under debate. This paper describes a functional evolutionary approach to assess the contribu ... ...
 
Development: Reinforcing feedback
Scritto da Nature Reviews: Genetics   
BiochimicaImai et al. have identified a role for Pinhead gene transcription in specifying ventral fate in the sea squirt Ciona intestinalis. Furthermore, the genomic position of Pinhead ? that is, adjacent to the bone morphogenic protein (Bmp) ligand antidorsa ... ...
 
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